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Hoxb8 Gene Polymorphism in Fur Chewing Chinchilla – A Preliminary Study

Guja, I., Niedbała, P.,& Łapiński, S.
Published 31-12-2017

DOI

http://dx.doi.org/10.22573/spg.ijals.017.s12200086

AUTHOR AFFILIATION

University of Agriculture in Krakow, Faculty of Animal Sciences, Mickiewicz Alley 24/28 30-059 Krakow, Poland (12) 662 40 79.

ARTICLE HISTORY

Received: Nov 2017 / Accepted: Nov 2017/ Published: Dec 2017

HOW TO CITE THIS ARTICLE

Guja, I., Niedbała, P., & Łapinski, S. (2017). Hoxb8 Gene Polymorphism in Fur Chewing Chinchilla – A Preliminary Study. Int. J. Agr. Life. Sci, 3(4), 214-216. doi: 10.22573/spg.ijals.017.s12200086.

COPYRIGHT

© 2017 Skyfox Publishing Group. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

COMPETING INTERESTS

The authors have declared that no competing interests exist.

ABSTRACT

The fur chewing in animals is being mentioned among the obsessive- compulsive disorders. It is a group of behavioral dysfunctions of unknown origin, occurring in almost all vertebrates. Hoxb8 gene is involved in embryonic development and is extensively expressed in the CNS, in the regions responsible for grooming behavior in mammals. The loss of function mutation in Hoxb8 gene induces phenotypic symptoms comparable to the human trichotillomania - obsessive – compulsive disorder, in the course of which the patients uncontrolled pluck their hair from different areas of the body. The aim of the study was to analyze Hoxb8 gene sequence in fur chewing chinchillas for the presence of single nucleotide polymorphisms (SNPs). On the basis of the analyzed sequences, the presence of two point mutations was detected: transversion A>C (g.1451C>A), resulting in the substitution of proline to glycine and the transition A>G (g.1654A>G), resulting in substitution of aspartic acid to glycine. In the analyzed group were detected both homozygous AA, GG, and heterozygous AG.