Anti-Inflammatory and antioxidant efficacy of Herbal Mixture on Anti-Inflammatory Paracetamol Induced hepatotoxicity
Bharathi. J*1 and Hazeena Begum. V1
Year : 2019 , Volume : 5 , Issue : 1
Department of Siddha Medicine, Faculty of Science, Tamil University, Thanjavur-613 010, Tamil Nadu.
*Author to whom correspondence should be addressed; E-Mail: firstname.lastname@example.org
Received: March 2019 / Accepted: March 2019 / Published: March 2019
ABSTRACT: The present study was carried out to investigate hepatoprotective effects of herbal mixture in female albino rats, in the paracetamol (PCM) induced hepatotoxicity model. Treatment of rats with herbal mixture at dose of (2g /kg for 4 weeks) significantly prevented the serum biomarker enzymes (AST and ALT). Herbal mixture further reduced PCM induced oxidative stress and inflammation in the rat liver by inhibiting lipid peroxidation and restoring the levels of antioxidant enzymes (PCO, LPO, MPO SOD, CAT, GSH, and HO-1). Our results indicate that herbal mixture can prevent hepatic injury with PCM induced hepatotoxicity by eliciting therapeutic protection against free radical stress and inflammation.
Keywords: Herbal Mixture, Glutathione, Hemeoxygenase (HO), Hepatotoxicity, Paracetamol (PCM)
DOI : http://dx.doi.org/10.22573/spg.ijals.019.s12200093