Elevating Health with Cordyceps Militaris: The Ultimate Food Supplement

Author : Sudharsan Parthasarathy¹, Gobalan Krishnasamy², Bupesh Giridharan¹, Koperuncholan Marimuthu³, Siva Vijayakumar Tharumasivam^4*
Mail Id : shiva.bloom165@gmail.com

Abstract

Cordyceps Militaris, a species of medicinal mushroom, has been revered in traditional Asian medicine for its potential health-enhancing properties. In recent years, scientific research has been exploring its nutritional composition and bioactive compounds, shedding light on its promising health benefits. This review paper provides an in-depth examination of Cordyceps Militaris as a food supplement, focusing on its potential health benefits, scientific evidence supporting its efficacy, and safety considerations. The nutritional profile of Cordyceps Militaris is diverse, comprising proteins, amino acids, polysaccharides, nucleosides, vitamins, minerals, and more, which work synergistically to offer potential advantages. Studies and traditional usage suggest that Cordyceps Militaris may support the immune system, enhance energy and endurance, possess anti-inflammatory and antioxidant properties, promote respiratory health, help regulate blood sugar levels, and have potential cardiovascular and neuroprotective effects. While scientific evidence supporting its efficacy is growing, caution is warranted, as more extensive human trials are required to draw definitive conclusions. Optimal dosage and usage guidelines are discussed, emphasizing the importance of consulting healthcare professionals before incorporating Cordyceps Militaris supplements into daily regimens. Safety considerations and precautions are outlined to address potential risks, particularly for individuals with allergies, underlying health conditions, or those taking medications. As research continues to unfold the potential of Cordyceps Militaris, this review paper provides valuable insights for those seeking to explore the realm of this ultimate food supplement.

References

1. Abdullah, S., & Kumar, A. (2023). A brief review on the medicinal uses of Cordyceps militaris. Pharmacol. Res. – Mod. Chin. Med., 100228. https://doi.org/10.1016/j.prmcm.2023.100228

2. ---

   Barido, F. H., Kang, S. M., & Lee, S. K. (2022). The quality and functional improvement of retorted Korean ginseng chicken soup (Samgyetang) by enzymolysis pre-treatment with Cordyceps militaris mushroom extract. Foods, 11(3), 422. https://doi.org/10.3390/foods11030422

3. ---

   Boontiam, W., Wachirapakorn, C., & Wattanachai, S. (2020). Growth performance and hematological changes in growing pigs treated with Cordyceps militaris spent mushroom substrate. World, 13(4), 768. https://doi.org/10.14202%2Fvetworld.2020.768-773

4. ---

   Boontiam, W., Wachirapakorn, C., Phaengphairee, P., & Wattanachai, S. (2020). Effect of spent mushroom (Cordyceps militaris ) on growth performance, immunity, and intestinal microflora in weaning pigs. Animals, 10(12), 2360. https://doi.org/10.3390/ani10122360

5. ---

   Chen, C., Han, Y., Li, S., Wang, R., & Tao, C. (2021). Nutritional, antioxidant, and quality characteristics of novel cookies enriched with mushroom (Cordyceps militaris ) flour. CyTA-J. Food, 19(1), 137-145. https://doi.org/10.1080/19476337.2020.1864021

6. ---

   Daba, G. (2020). The endless nutritional and pharmaceutical benefits of the Himalayan gold, Cordyceps; Current knowledge and prospective potentials. Asian J Nat Prod Biochem, 18(2). https://doi.org/10.13057/biofar/f180204

7. ---

   Fijałkowska, A., Jędrejko, K., Sułkowska-Ziaja, K., Ziaja, M., Kała, K., & Muszyńska, B. (2022). Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder. Foods, 11(10), 1489. https://doi.org/10.3390/foods11101489

8. ---

   Fijałkowska, A., Jędrejko, K., Sułkowska-Ziaja, K., Ziaja, M., Kała, K., & Muszyńska, B. (2022). Edible mushrooms as a potential component of dietary interventions for major depressive disorder. Foods, 11(10), 1489. https://doi.org/10.3390/foods11101489

9. ---

   Gariboldi, M. B., Marras, E., Ferrario, N., Vivona, V., Prini, P., Vignati, F., & Perletti, G. (2023). Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. Int. J. Mol. Sci., 24(12), 10120. https://doi.org/10.3390/ijms241210120

10. ---

    Hu, D., Yang, X., Hu, C., Feng, Z., Chen, W., & Shi, H. (2021). Comparison of ergosterol and Vitamin D2 in mushrooms agaricus bisporus and Cordyceps militaris using ultraviolet irradiation directly on dry powder or in ethanol suspension. ACS omega, 6(44), 29506-29515. https://doi.org/10.1021/acsomega.1c03561

11. ---

    Hur, H. Chemical ingredients of C. militaris. Mycobiology, 2008, 36(4), 233-235. https://www.tandfonline.com/doi/abs/10.4489/MYCO.2008.36.4.233

12. ---

    Jędrejko, K. J., Lazur, J., & Muszyńska, B. C. militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity. Foods, 2021, 10(11), 2634. https://doi.org/10.3390/foods10112634

13. ---

    Jędrejko, K., Kała, K., Sułkowska-Ziaja, K., Krakowska, A., Zięba, P., Marzec, K., … & Muszyńska, B. (2022). Cordyceps militaris —Fruiting bodies, mycelium, and supplements: Valuable component of daily diet. Antioxidants, 11(10), 1861. https://doi.org/10.3390/antiox11101861

14. ---

    Ji, D. B., Ye, J., Li, C. L., Wang, Y. H., Zhao, J., & Cai, S. Q. Antiaging effect of Cordyceps sinensis extract. Phytother Res., 2009, 23(1), 116-122. https://doi.org/10.1002/ptr.2576

15. ---

    Jing, X. Cui, Z. Chen, L. Huang, L. Song, T. Liu, W. Lv, R. Yu, Elucidation and biological activities of a new polysaccharide from cultured C. militaris, Carbo. Poly. 102 2014, 288-296. https://doi.org/10.1016/j.carbpol.2013.11.061

16. ---

    Khuntawee, W., Amornloetwattana, R., Vongsangnak, W., Namdee, K., Yata, T., Karttunen, M., & Wong-ekkabut, J.. In silico and in vitro design of cordycepin encapsulation in liposomes for colon cancer treatment. RSC Adv., 2021, 11(15), 8475-8484. https://pubs.rsc.org/en/content/articlehtml/2021/ra/d1ra00038a

17. ---

    Kim, S. B., Ahn, B., Kim, M., Ji, H. J., Shin, S. K., Hong, I. P., et. al., Effect of C. militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL/6J mice. J. Ethnopharmacol., 2014, 151(1), 478-484. https://doi.org/10.1016/j.jep.2013.10.064

18. ---

    Kopalli, S. R., Cha, K. M., Lee, S. H., Hwang, S. Y., Lee, Y. J., Koppula, S, et. al., Cordycepin, an active constituent of nutrient powerhouse and potential medicinal mushroom C. militaris Linn., ameliorates age-related testicular dysfunction in rats. Nutrients, 2019, 11(4), 906. https://doi.org/10.3390/nu11040906

19. ---

    Kusama, K., Miyagawa, M., Ota, K., Kuwabara, N., Saeki, K., Ohnishi, Y., et. al.,. C. militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy. Nutrients, 2021, 13(1), 50. https://doi.org/10.3390/nu13010050

20. ---

    Lee, M. R., Kim, J. E., Choi, J. Y., Park, J. J., Kim, H. R., Song, B. R., et. al., Anti obesity effect in high fat diet induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with C. militaris. Exp Ther Med, 2019, 17(3), 2185-2193. https://doi.org/10.3892/etm.2019.7191

21. ---

    Li, X. T., Li, H. C., Li, C. B., Dou, D. Q., & Gao, M. B. Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of C. militaris. Am. J. Chinese Med. 2010, 38(06), 1093-1106. https://doi.org/10.1142/S0192415X10008494

22. ---

    Lin, R., Liu, H., Wu, S., Pang, L., Jia, M., Fan, K., et. al.,. Production and in vitro antioxidant activity of exopolysaccharide by a mutant, C. militaris SU5-08. Int. J. Biol. Macromol. 2012, 51(1-2), 153-157. https://doi.org/10.1016/j.ijbiomac.2012.04.011

23. ---

    Liu, J. Y., Feng, C. P., Li, X., Chang, M. C., Meng, J. L., & Xu, L. J. (2016). Immunomodulatory and antioxidative activity of C. militaris polysaccharides in mice. Int. J. Biol. Macromol. 86, 594-598. https://doi.org/10.1016/j.ijbiomac.2016.02.009

24. ---

    Liu, X., Huang, Y., Chen, Y., & Cao, Y. (2016). Partial structural characterization, as well as immunomodulatory and anti-aging activities of CP2-c2-s2 polysaccharide from C. militaris. RSC adv., 6(106), 104094-104103. https://doi.org/10.1039/C6RA23612J

25. ---

    Mao, X. B., Eksriwong, T., Chauvatcharin, S., & Zhong, J. J. (2005). Optimization of carbon source and carbon/nitrogen ratio for cordycepin production by submerged cultivation of medicinal mushroom C. militaris. Process Biochem, 40(5), 1667-1672. https://doi.org/10.1016/j.procbio.2004.06.046

26. ---

    Omak, G., & Yilmaz-Ersan, L. (2022). Effect of Cordyceps militaris on formation of short-chain fatty acids as postbiotic metabolites. Prep. Biochem. Biotechnol., 52(10), 1142-1150. https://doi.org/10.1080/10826068.2022.2033992

27. ---

    Phull, A. R., Ahmed, M., & Park, H. J.  Cordyceps militaris as a bio functional food source: pharmacological potential, anti-inflammatory actions and related molecular mechanisms. Microorganisms, 2022, 10(2), 405. https://doi.org/10.3390/microorganisms10020405

28. ---

    Phull, A. R., Ahmed, M., & Park, H. J. (2022). C. militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms. Microorganisms, 10(2), 405. https://doi.org/10.3390/microorganisms10020405

29. ---

    Rao, Y. K., Fang, S. H., Wu, W. S., & Tzeng, Y. M. (2010). Constituents isolated from C. militaris suppress enhanced inflammatory mediator’s production and human cancer cell proliferation. J. Ethnopharmacol., 131(2), 363-367. https://doi.org/10.1016/j.jep.2010.07.020

30. ---

    Reis, F. S., Barros, L., Calhelha, R. C., Ćirić, A., Van Griensven, L. J., Soković, M., & Ferreira, I. C. (2013). The methanolic extract of C. militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties. Food Chem Toxicol, 62, 91-98. https://doi.org/10.1016/j.fct.2013.08.033

31. ---

    Yang, L. Jin, X. Ren, J. Lu, Q. Meng, Optimization of fermentation process of C. militaris and antitumor activities of polysaccharides in vitro. J Food Drug Anal, 22(4) (2014) 468-476. https://doi.org/10.1016/j.jfda.2014.01.028

32. ---

    Shrestha, B., Zhang, W., Zhang, Y., & Liu, X. (2012). The medicinal fungus C. militaris: research and development. Mycol. Prog., 11(3), 599-614. https://link.springer.com/article/10.1007/s11557-012-0825-y

33. ---

    Sripilai, K., Chaicharoenaudomrung, N., Phonchai, R., Chueaphromsri, P., Kunhorm, P., & Noisa, P. (2023). Development of an animal-free nitrogen source for the liquid surface culture of Cordyceps militaris.       Appl. Microbiol., 76(5), ovad053. https://doi.org/10.1093/lambio/ovad053

34. ---

    Tang, H., Ye, Z. W., Liu, C., Guo, L. Q., Lin, J. F., Wang, H., … & Kang, L. (2019). Increasing of the contain of carotenoids in Caterpillar mushroom, Cordyceps militaris (Ascomycetes) by using the fungal elicitors cultivation. Int. J. Med. Mushrooms, 21(12). https://doi.org/10.1615/IntJMedMushrooms.2019032998

35. ---

    Taştekin, N. H., & Özenver, N. Cordyceps militaris (L.): Medicinal Aspects in Terms of Ethnobotanical and Pharmacological Perspectives. In Mushrooms with Therapeutic Potentials: Recent Advances in Research and Development 2023, (pp. 345-367). Nat.. https://doi.org/10.1007/978-981-19-9550-7_12

36. ---

    Topczewska, J., Lechowska, J., Kaszuba, J. et al. Culinary trails in popularizing ethnic cuisines. J. Ethn. Food., 9, 43 (2022). https://doi.org/10.1186/s42779-022-00158-z

37. ---

    Wang, L., Yan, H., Zeng, B., & Hu, Z. (2022). Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in C. militaris. Bioeng., 9(2), 69. https://doi.org/10.3390/bioengineering9020069

38. ---

    Wang, L., Zhang, W. M., Hu, B. A., Chen, Y. Q., & Qu, L. H. (2008). Genetic variation of C. militaris and its allies based on phylogenetic analysis of rDNA ITS sequence data. Fungal Divers., 31, 147-155. https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doifc043d563f8f8779b9cfcdc6cf64f59badb94ef3

39. ---

    Wang, M., Meng, X. Y., Le Yang, R., Qin, T., Wang, X. Y., Zhang, K. Y., et. al., (2012). C. militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice. Carbohydr. Polym., 89(2), 461-466. https://doi.org/10.1016/j.carbpol.2012.03.029

40. ---

    Wu, C. Y., Liang, C. H., & Liang, Z. C. (2022). Enhanced production of fruiting bodies and bioactive compounds of C. militaris with grain substrates and cultivation patterns. J Taiwan Inst Chem Eng 132, 104138. https://doi.org/10.1016/j.jtice.2021.11.005

41. ---

    Wu, L., Sun, H., Hao, Y., Zheng, X., Song, Q., Dai, S., & Zhu, Z. (2020). Chemical structure and inhibition on α-glucosidase of the polysaccharides from C. militaris with different developmental stages. Int. J. Biol. Macromol., 148, 722-736. https://doi.org/10.1016/j.ijbiomac.2020.01.178

42. ---

    Wu, S., Wu, Q., Wang, J., Li, Y., Chen, B., Zhu, Z., … & Ding, Y. (2022). Novel selenium peptides obtained from selenium-enriched Cordyceps militaris alleviate neuroinflammation and gut microbiota dysbacteriosis in LPS-injured mice. J. Agric. Food Chem., 70(10), 3194-3206. https://doi.org/10.1021/acs.jafc.1c08393

43. ---

    Xin, X., Yin, J., Zhang, B., Li, Z., Zhao, S., & Gui, Z. (2019). Genome-wide analysis of DNA methylation in subcultured C. militaris. Arch. Microbiol., 201(3), 369-375. https://doi.org/10.1007/s00203-019-01621-3

44. ---

    Xu, L., Wang, F., Zhang, Z., & Terry, N. (2019). Optimization of polysaccharide production from Cordyceps militaris by solid-state fermentation on rice and its antioxidant activities. Foods, 8(11), 590. https://doi.org/10.3390/foods8110590

45. ---

    Yu, M., Yue, J., Hui, N., Zhi, Y., Hayat, K., Yang, X., et. al., (2021). Anti-hyperlipidemia and gut microbiota community regulation effects of selenium-rich C. militaris polysaccharides on the high-fat diet-fed mice model. Foods, 10(10), 2252. https://doi.org/10.3390/foods10102252

46. ---

    Zhan, Y., Dong, C. H., & Yao, Y. J. (2006). Antioxidant activities of aqueous extract from cultivated fruit‐bodies of C. militaris (L.) Link in vitroJ. Integr. Plant Biol.48(11), 1365-1370. https://doi.org/10.1111/j.1744-7909.2006.00345.x

47. ---

    Zhang, X. M., Tang, D. X., Li, Q. Q., Wang, Y. B., Xu, Z. H., Li, W. J., et. al., (2021). Complex microbial communities inhabiting natural C. militaris and the habitat soil and their predicted functions. ANTON LEEUW INT J G, 114(4), 465-477. https://doi.org/10.1007/s10482-021-01534-6

48. ---

    Zhang, Y., Zeng, Y., Cui, Y., Liu, H., Dong, C., & Sun, Y. (2020). Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from C. militaris cultivated on hull-less barley. Carbohydr. Polym., 235, 115969. https://doi.org/10.1016/j.carbpol.2020.115969

49. ---

    Zhao, Y., Li, S. L., Chen, H. Y., Zou, Y., Zheng, Q. W., Guo, L. Q., et. al., (2021). Enhancement of carotenoid production and its regulation in edible mushroom Cordyceps militaris by abiotic stresses. Enzyme Microb. Technol., 148, 109808. https://doi.org/10.1016/j.enzmictec.2021.109808

50. ---

    Zheng, P., Xia, Y., Xiao, G., Xiong, C., Hu, X., Zhang, S., et. al., (2012). Genome sequence of the insect pathogenic fungus C. militaris, a valued traditional Chinese medicine. Genome Biol. 12(11), 1-22. https://doi.org/10.1186/gb-2011-12-11-r116

51. ---

    Zhu, Z. Y., Liu, F., Gao, H., Sun, H., Meng, M., & Zhang, Y. M. (2016). Synthesis, characterization and antioxidant activity of selenium polysaccharide from C. militaris. J. Biol. Macromol., 93, 1090-1099. https://doi.org/10.1016/j.ijbiomac.2016.09.076

52. ---

    Zhu, Z., Huang, A., Chen, M., Wang, J., Li, Z., Sun, Z., … & Ding, Y. (2023). Impacts of selenium enrichment on nutritive value and obesity prevention of Cordyceps militaris: A nutritional, secondary metabolite, and network pharmacological analysis. Food Chem.: X, 100788. https://doi.org/10.1016/j.fochx.2023.100788.

53. ---

    Zou, Y., Yu, X., Zheng, Q., Ye, Z., Wei, T., Guo, L., & Lin, J. (2022). Effect of beating process on the physicochemical and textural properties of meat analogs prepared with Cordyceps militaris fruiting body. Int. J. Food Eng., 18(2), 153-160. https://doi.org/10.1515/ijfe-2021-0322

Author information

Authors and Affiliations

¹Department of Forestry, Nagaland University (A Central University), Lumami, Nagaland, India

²Department of Biotechnology, Jamal Mohamed College (Autonomous), Trichy, Tamil Nadu, India

³Department of Botany, Srimad Andavan Arts and Science College (Autonomous), Trichy, Tamil Nadu, India

⁴Department of Biotechnology Engineering, Dhanalakshmi Srinivasan university, Samayapuram, Trichy, Tamil Nadu, India

*Corresponding author. Email: shiva.bloom165@gmail.com

Editor Information

Editors and Affiliations

Department of Academics and Human Resource Development

National Institute of Food Technology, Entrepreneurship and Management, Thanjavur (NIFTEM-T)

(An Institute of National Importance)

Ministry of Food Processing Industries (MoFPI), Govt. of India

Thanjavur, Tamil Nadu, India. Pin Code – 613005

Dr. S. Vignesh

Dr. N. Baskaran

Dr. M. Loganathan

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