Hoxb8 Gene Polymorphism in Fur Chewing Chinchilla – A Preliminary Study

Authors

  • Guja, I University of Agriculture in Krakow, Faculty of Animal Sciences, Mickiewicz Alley 24/28 30-059 Krakow, Poland (12) 662 40 79.
  • Niedbała, P University of Agriculture in Krakow, Faculty of Animal Sciences, Mickiewicz Alley 24/28 30-059 Krakow, Poland (12) 662 40 79
  • Łapiński, S University of Agriculture in Krakow, Faculty of Animal Sciences, Mickiewicz Alley 24/28 30-059 Krakow, Poland (12) 662 40 79

Keywords:

Hoxb8 gene, fur chewing, chinchilla

Abstract

The fur chewing in animals is being mentioned among the obsessive- compulsive disorders. It is a group of behavioral dysfunctions of unknown origin, occurring in almost all vertebrates. Hoxb8 gene is involved in embryonic development and is extensively expressed in the CNS, in the regions responsible for grooming behavior in mammals. The loss of function mutation in Hoxb8 gene induces phenotypic symptoms comparable to the human trichotillomania - obsessive – compulsive disorder, in the course of which the patients uncontrolled pluck their hair from different areas of the body. The aim of the study was to analyze Hoxb8 gene sequence in fur chewing chinchillas for the presence of single nucleotide polymorphisms (SNPs). On the basis of the analyzed sequences, the presence of two point mutations was detected: transversion A>C (g.1451C>A), resulting in the substitution of proline to glycine and the transition A>G (g.1654A>G), resulting in substitution of aspartic acid to glycine. In the analyzed group were detected both homozygous AA, GG, and heterozygous AG.

References

Bachmann I., Stauffacher M., Prevalence of behavioral disorders in the Swiss horse population, Schweizer Archiv fur Tierheilkunde 144: 356-368, 2002.

Capecchi MR., Hox genes and mammalian development, Cold Spring Harb Symp Quant Biol 62: 273- 281, 1997.

Chou-Green JM., Holscher TD., Dallman MF., Akana SF., Compulsive behavior in the 5-HT2C receptor knockout mouse, Physiol Behav 78: 641-649, 2003.

Dodman N., Oliver B., In search of animal models for obsessive-compulsive disorder, CNS Spectrums 1: 10-15, 1996.

Garner JP., Weisker SM., Dufour B., Mench JA, Barbering (fur and whisker trimming) by laboratory mice as a model of human trichotillomania and obsessivecompulsive spectrum disorders, Comp Med 54: 216-224, 2004.

Greer JM., Capecchi MR., Hoxb8 is required for normal grooming behavior in mice, Neuron 33: 23-34, 2002.

Jenkins JR, Feather picking and self-mutilation in psittacine birds, Veterinary Clinics of North America: Exotic Animal Practice, 4: 651-667, 2001.

Kurien T., Gross T., Scofield RH., Barbering in mice: a model for trichotillomania, BMJ 331(7531): 1503– 1505, 2005.

Owen LN, Canine lick granuloma treated with radioteraphy, Journal of Small Animal Practice 8: 454- 456, 2008.

Ponzio MF., Monfort SL., Busso JM., Carlini VP., Ruiz RD. i in., Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera), Hormones and Behavior 61: 758- 762, 2012.

Rauch SL, Whalen PJ, Curran T, Shin LM, Coffey BJ, Savage CR, McInerney SC, Baer L, Jenike MA, Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods, Adv Neurol., 85:207-24, 2001.

Spruijt BM., van Hoof JA., Gispen WH., Ethology and neurobiology of grooming behavior, Physiol Rev Jul 72(3): 825-852, 1992.

Welch JM., Lu J., Rodriguez RM., Trotta NC., Peca J. i in., Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice, Nature 448(7156): 849-900, 2007.

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Published

31.12.2017

Issue

Vol. 3 No. 4 (2017)

Section

Research Article

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Hoxb8 Gene Polymorphism in Fur Chewing Chinchilla – A Preliminary Study. (2017). International Journal of Agricultural and Life Sciences, 3(4), 214-216. https://skyfox.co/ijals/index.php/als/article/view/35