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Anti-Inflammatory and antioxidant efficacy of Herbal Mixture on Anti-Inflammatory Paracetamol Induced hepatotoxicity

Bharathi. J*1 and Hazeena Begum. V1
Published 31-03-2019

DOI

http://dx.doi.org/10.22573/spg.ijals.019.s12200093

AUTHOR AFFILIATION

1.Department of Siddha Medicine, Faculty of Science, Tamil University, Thanjavur-613 010, Tamil Nadu.

ABSTRACT

The present study was carried out to investigate hepatoprotective effects of herbal mixture in female albino rats, in the paracetamol (PCM) induced hepatotoxicity model. Treatment of rats with herbal mixture at dose of (2g /kg for 4 weeks) significantly prevented the serum biomarker enzymes (AST and ALT). Herbal mixture further reduced PCM induced oxidative stress and inflammation in the rat liver by inhibiting lipid peroxidation and restoring the levels of antioxidant enzymes (PCO, LPO, MPO SOD, CAT, GSH, and HO-1). Our results indicate that herbal mixture can prevent hepatic injury with PCM induced hepatotoxicity by eliciting therapeutic protection against free radical stress and inflammation.

ARTICLE HISTORY

Received: March 2019 / Accepted: March 2019 / Published: March 2019

COPYRIGHT

© 2019 Bharathi J et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the Original work is properly cited.

COMPETING INTERESTS

The authors have declared that no competing interests exist.

HOW TO CITE THIS ARTICLE

Bharathi, J., & Hazeena Begum, V. (2019). Anti-Inflammatory and antioxidant efficacy of Herbal Mixture on Anti-Inflammatory Paracetamol Induced hepatotoxicity. Int J Agr Life Sci, 5(1), 252-258. doi: 10.22573/spg.ijals.019.s12200093.


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