In Effect of Poorna Chandrodayam Chendooram (metallic drug) on liver function, kidney function and lipid profile parameters of rats
Keywords:
PCM, TG, TL, LDL, HDL, SGPT, SGPT and ALPAbstract
Poorna chandrodayam chendooram (PCM), a Siddha preparation which is used for its effect on liver function, kidney function and lipid profile after administrations into the biological system. The experimental animal model was of Male rats. Triglycerides (TG) Total cholesterol (TC), and low density lipoprotein (LDL) were decreased in experimental groups whereas high density lipoprotein (HDL) were slightly increased in male rats. The total protein and albumin content of plasma were increased very high significantly. In case of bilirubin, the decrease was negligible for rats. The serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and alkaline phosphatase (ALP) content in the plasma were decreased very high significantly in the experimental groups. Creatinine, and urea were decreased in male where only change of uric acid level was significant increased.
References
Austin A., M. Jagadeesan and S. Subramanian. (2002)Toxicological studies of Linga chendooram: a Siddha Drug. Indian J.Pharm.Sci.; 64:53-58.
Doumas, B.T., W. A. Watson and H. G. Biggs, (1971). Albumin standards and measurement of serum-albumin with bromocresol green. Clin. Chim. Acta. 31(1): 87- 96.
Eidi, A., M. Eidi and E. Esmaeili, (2006). Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-diabetic rats.
Phytomedicine, 13 (9-10): 624-629.
Evelyn, K.A. and Malloy H. T.( 1938). Microdetermination of Oxyhemoglobin, Methemoglobin and Sulfhemoglobin in a single sample of Blood. J. Biol. Chem. 126, 655 -662.
Flora, S.J.S., Mathur, S., Mathur, R (1995). Effects of meso 2,3 –dimercapto succinic acid or 2,3 –dimercapto 1-sulfonate on beryllium induced biochemical alteration and metal concentration in male rats.Toxicology, 95, 167.
Friedewald, W.T., R.I. Levy and D.S. Fredrickson, (1972). Estimation of the concentration of Low-Density Lipoprotein Cholesterol in plasma, without use of the preparative ultracentrifuge, Clinical Chemistry, 18(6): 499-502.
Gebhardt, R. and Beck H. (1996). Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids, 31(12):1269- 1276.
Guyton, C. (1991) Ed. Text book of Medical Physiology. Saunders. New York.
Halliwell, B. (1998). Albumin: an important extracellular antioxidant, Biochem Pharmacol., 37, 569–571.
Hardy AD., H.H. Sutherland, R. Vaishnav and M.A. Worthing. A report on the composition of mercurials used in the traditional medicines in Oman. J. Ethnopharmacol.1995; 49:17-22. 13.
Harper, H.A. (1991). Haper‟s review of biochemistry In: Murray, R.K., Mayes, P.A., Granner, D.K., and Rodwel, V.W. (eds). Large medical publication. London pp. 450-453.
Hazeena Begum V, Muthukumaran P(2014). Phytochemical and free radical scavenging activity of Poorna chandrodayam chendooram (metallic herbal based drug). The Journal of Phytopharmacology , 3(6): 418-422
Zilva, JF Panmall P. R. and Mayne, P. D. (1991). Clinical Chemistry in Diagnosis and Treatment, England Clays Ltd., St. Ives Plc., England, 5th edition.
Kaplan, A.P. 1965. Urea nitrogen and urinary ammonia. In: Standard Method of Clinical Chemistry, Meites S., Academic Press Inc., New York, pp: 245 – 256.
Kharb, S. and Singh ,V. (2004).Total free radical trapping antioxidant potential in normal pregnancy. J Obstet Gynecol Ind . 54(3), 249-50.
Kumar,A.,A.G.Nair, A.V.Reddy and A.N.Garg. .Bhasmas:Unique ayurvedic metallic herbal preparations,chemical characterization. Biol.Trace Elem.Res. 2006; 109:231-254.
Lee, K.T., I.C. Sohn, D.H. Kim, J.W. Choi, S.H. Kwon and H.J. Park, 2000. Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-induced diabetic rat and their antioxidant activity in vitro. Arch. Pharm. Res., 23: 461-466.
Mahdihassan, S. Cinnabar. Gold as a best alchemical drug of longevity called Makaradhwaja in india. Am J Chin Med. 1985; 13:93-108.
Martin, D.W.Jr., Mayes, P.A and Rodwell, V.W. (1981). Harper‟s review of biochemistry. 18th edn. (Lange medical publication Califonia), 61.
Mazumder, U.K., Gupta, N., Chakrabarti, S. and Pal, D. (1999). Evaluation of hematological and hepato renal functions of methanolic extract of Moringa oleifera (Lam) root treated mice, Ind J Expl Biol., 37, 612-614.
Mironova, M.A., R. L. Klein, G.T. Virella and M.F. Lopes-Virella, 2000. Anti-modified LDL antibodies, LDL-containing immune complexes and susceptibility of LDL to in vitro oxidation in patients with type -2 diabetes. Diabetes, 49:1033-1049.
Mitchell, F.L., and Watts, R. W. E. (1972). Renal function tests suitable for clinical practice. Ann. Clin. Biochem. 9, 1- 20.
Mitchell, J. M., Jr.(1972), The Natural Breakdown of the Present Interglacial and its Possible Intervention by Human Activities, Quatern. Res., 2, 436– 445.
Muthaliar, K.N.K and Uttamarayan K.S. (1987).Siddha Pharmacopoeia . Parinilayam,Chennai, pp:167-168.
Naganna, B. (1989). Plasma proteins. In: Textbook of Biochemistry and Human Biology, Talwar
NCEP (Third Report of the National Cholesterol Educaction Program) (2002). Expert panel on detection, evaluation and treatment of high blood cholesterol in adult (Adult Treatment Panel III) final report. Circulation, 106: 3143-3421.
Nwanjo, H.U. (2004). Lipids and Lipoproteins in Biochemistry for Students of Pathology. 1st Edn., Laudryman, Nigeria
Patel NG(1986).Ayurveda: the traditional medicine of India, in Folk Medicine; The Art and the Science, RP Steiner ed. American Chemical Society, Washington, DC, pp. 41–65.
Pepato, M.T., A.M. Baviera, R.C. Vendramini, M.P. Perez, I.C. Kettelhut and I.L. Brunetti, (2003). Cissus sicyoides (Princess wine) in the long term treatment of streptozotocin-diabetic rats. Biotechnol. Applied Biochem., 37:15-20.
Plummer, D.T. (1971). An Introduction to Practical Biochemistry. McGraw-Hill, London, 2nd edn, pp: 144-145.
Raju, SM, Bindu M (2005). Illustrated Medical Biochemistry, 1st ed. Brjbasi Press Ltd. New Delhi, 152-153.
Ronald, L., and Koretz, M.D. (1992). Chronic hepatitis: Science and superposition. In: Gitnick, G (ed). Current hepatology. Mosby, Chicago II.
Ross, R. N.,( 1999). Atherosclerosis — An Inflammatory Disease. Eng. J. Med., 340: 115-126.
Savrikar SS (2004) Use of metallic/mineral medicinal preparations in the management of disease, in Proc. Seminar on Metals in Medicine; Ayurvedic and Modern View, p. 16–18.
Shahjahan, M., K. E. Sabitha, J. M. and C. S. Shyamala-Devi, (2004). Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats, Indian J. Med. Res, 120: 194-198
Sharma, M. K., A.K. Khare and H. Feroz,(1983). Effect of neem oil on blood glucose levels of normal, hyperglycemic and diabetic animals. Indian Med. Gaz., 117: 380-383.
Srivastava L. M. and Moudgil, K. D., Prentice- Hall of India Private Ltd., New- Delhi, 2nd edn.; pp: 59 – 61.
Sudha, A.,V.S.Murty and T.S.Chanda(2009). Standardization of metal based herbal medicines. Am. J. Infect. Dis. 5:193-199.
Suoboda RE. (1998).Prakriti; Your Ayurvedic Constitution, 2nd ed., Sadhana Publications, Bellingham, WA, pp. 169–174.
Thiagarajan, R (1992). Directorate of Indian Medicine and Homeopathy .Tamilnadu, Chennai. pp.134-144.
Tietz, N.W., E. L. Prude and O. Sirgard-Anderson, (1994). Tietz Textbook of Clinical Chemistry.ed. Burtis C. A. and Ashwood, E. R., W. B. Saunders Company, London, 2nd edn; pp: 1354 – 1374.
Virella-Lopes, M.F. and G. Virella, (2003). The role of immune and inflammatory processes in the development of macrovascular disease in diabetes. Frontiers Biosc, 8:750-768.
Wright, P.J. and D. T. Plummer (1974). The use of urinary enzyme measurement to detect renal damage caused by nephrotoxic compounds. Biochem.Pharmacol., 23(1): 65-73.
Yeragi, S.G., Koli, A. and Yeragi, S. (2000). Effect of pesticide malathion on protein metabolism of the marine crab, Uca marionis. J.Ecotoxicol.Environ Monot., 10, 59-62.
Published
Versions
- 17.12.2016 (3)
- 17.12.2016 (1)
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journals offer different licence options, please see the Instructions to Authors page of the relevant journal for more information.
Books and book chapters
When publishing a book, or a chapter in a book, the terms of licensing and copyright will typically be included in a contract which you would have to agree with a publisher and which will specify the usage rights, the format(s) and length of time applied to the work.
Book contracts vary from publisher to publisher, and can in some cases be complicated. If you are required to sign a contract with a publisher in order to publish your work you need to ensure that the contract covers your rights and that it takes into account the obligation you have to your employer and/or the funder of your research.
If you want to publish a thesis or dissertation it is recommended that you contact your institution or department to make sure that you follow their policy for such publications.
Kindly Check the concern book title for How To Cite. Plese ignore if any citation format provided in Book Section